Grant made her debut as a teenager, and gained fame in Christian music during the 1980s with such hits as "Father's Eyes", "El Shaddai", and "Angels". In the mid-1980s, she began broadening her audience and soon became one of the first CCM artists to cross over into mainstream pop on the heels of her successful albums Unguarded and Lead Me On. In 1986, she scored her first Billboard Hot 100 No. 1 song in a duet with Peter Cetera, "The Next Time I Fall". In 1991, she released the blockbuster album Heart in Motion which became her best-selling album to date, topping the Billboard Christian album chart for 32 weeks, selling five million copies in the U.S., and producing her second No. 1 pop single "Baby Baby".
Grant has won six Grammy Awards, 22 Gospel Music Association Dove Awards, and had the first Christian album ever to go Platinum. She was honored with a star on Hollywood Walk of Fame in 2005 for her contributions to the entertainment industry.